You'd need an app which has access to file system events.
Wire can't do that at this time unfortunately.
Maybe the user could press a button when they save the file, which would then send OSC to Resolume or a Wire patch?
Though if you are trying to overwrite files in Resolume while they are loaded, that will lead to unexpected things happening.
Software developer, Sound Engineer,
Control Your show with ”Enter” - multiple Resolume servers at once - SMPTE/MTC column launch
try for free: http://programs.palffyzoltan.hu
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Making custom nodes for Wire is not possible currently.
Well, there is ISF, but that doesn't have access to the file system.
FFGL plugins loaded in Resolume could have access to the file system, or a custom app you write could do what you want through the API.
Software developer, Sound Engineer,
Control Your show with ”Enter” - multiple Resolume servers at once - SMPTE/MTC column launch
try for free: http://programs.palffyzoltan.hu
VJ footage: https://goo.gl/58oHy7
Like Zoltan mentioned the rest-api would be the best way to go about this.
It has support for loading files as well as sources. https://resolume.com/support/en/restapi
The rest-api can be used from almost any language and its easy to work with.