Resolume Forum

I feel like I'm missing something here. When I assign a slice to a layer, the blend mode for said layer stops working.

I believe that slices are always "alpha" mode no matter what.

You could put your image layer and mask layer together in a group, and have that group assigned to a slice. The slice would then have the transparency from that mask.

If I want to mask the overall output with layer that needs it's own slice controls, I'll turn that layer into a black overlay (auto-mask effect + levels).

When you take a layer texture for a slice, you essentially bypass anything that happens in the composition, including layer blending.
https://resolume.com/support/en/slice-r ... ce-routing

https://resolume.com/support/en/transfo ... -transform might be what you're looking for.