Yes. This has to do with the Control Surface recognition for the APC 40 in Resolume. The Control Surface recognition is the Generic / Ableton Live mode dropdown, we use this to put the APC in the correct 'mood'.
In order to see if it's an APC40, we need to send some midi to it and get it back. On a PC, only one application can access a device. So when another app already has the APC40 in use, this can cause a crash.
We're looking into improving this, along with better support for the APC20 and the APC40 Mk2.