Finally the bug where a black window was shown on an eGPU has been solved in 5.1.4 which means I no longer need Spout and Visution Mapio to get around the problem.(Though it was quie a nice learning experience)
Really nice to have full use of outputs in Resolume without having to use Spout.
However...
Playing one layer of full HD to one full HD output results in around 30 FPS.
Using the exact same composition in 5.1.2 I can play atleast 16 full HD on 4 x full HD outputs in 60 FPS, sending it with spout to Mapio and from there, also in 60 FPS (well, 59.9x fps) to my 4 full HD outputs.
I use a Razer Core with an MSI GTX 1080 Gaming Card on an Intel Skull Canyon.
Either way, great with an update.
Cheers