Is hard to undestand what are you asking for.
Columns are something like an array between layers, in example,
Column 1 means:
clip 1 layer 1
clip 1 layer 2
clip 1 layer 3..
So, playing a 'column' will play only one clip per layer.
About resolution, full HD is 1920x1080, your size is common 4K. If you want to knonw if resolume can play it, the answer is YES. It depends of your hardware, there's not a limitation on the resolume side (at least on my knowledge).
In fact, you will find guys playing far bigger resolutions around here.